Melanosomes: Biogenesis, Properties, and Evolution of an Ancient Organelle
نویسندگان
چکیده
منابع مشابه
Mitochondria and Melanosomes Establish Physical Contacts Modulated by Mfn2 and Involved in Organelle Biogenesis
BACKGROUND To efficiently supply ATP to sites of high-energy demand and finely regulate calcium signaling, mitochondria adapt their metabolism, shape, and distribution within the cells, including relative positioning with respect to other organelles. However, physical contacts between mitochondria and the secretory/endocytic pathway have been demonstrated so far only with the ER, through struct...
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Melanosomes make pigments and mitochondria make ATP. A recent study has shown that these two organelles are connected by fibrillar bridges and that their close physical contact may promote the biogenesis of the melanosome by providing it with ATP.
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What controls the dynamics of the transitional ER? Secretory proteins exit from the endoplasmic reticulum (ER) at specialized transitional ER (tER) sites. Benjamin Glick (University of Chicago) described the role of Sec16 in regulating tER organization in the yeast Pichia pastoris. Membrane-associated Sec16 seems to slow ER export. A mutation that redistributes Sec16 to the cytosol relieves thi...
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Is mitochondrial volume maintained during polarized cell growth? How well do cells ensure that they maintain uniform organelle distribution when they undergo polarized cell growth and subsequent division. S. Rafelski from the Marshall laboratory at University of California–San Francisco used three-dimensional, computationalmodeling methods to demonstrate that mitochondrial volume is maintained ...
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an organism are compared. In mammals, for example, the ER is vastly abundant in exocrine pancreatic secre-where there is no appreciable demand for the secretion of any protein (Bolender, 1974). Using representative examples primarily from the yeast Saccharomyces cere-One hallmark of eukaryotic cells is that they contain visiae, we highlight in this review some recent insights many functionally ...
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ژورنال
عنوان ژورنال: Physiological Reviews
سال: 2019
ISSN: 0031-9333,1522-1210
DOI: 10.1152/physrev.00059.2017